The evolution, evolvability and engineering of gene regulatory DNA - Nature.com

3/9/2022 12:00:00 AM3 years 1 month ago

A framework for studying and engineering gene regulatory DNA sequences, based on deep neural sequence-to-expression models trained on large-scale libraries of random DNA, provides insight into the evolution, evolvability and fitness landsc…

  • Wittkopp, P. J. & Kalay, G. Cis-regulatory elements: molecular mechanisms and evolutionary processes underlying divergence. Nat. Rev. Genet.13, 5969 (2011). PubMed  Google Scholar 
    • full article...