Muskelin regulates actin-dependent synaptic changes and intrinsic brain activity relevant to behavioral and cognitive processes | Communications Biology - Nature.com

A murine muskelin knockout induces increased exploratory drive and alters cognition and functional connectivity. These effects correlate with actin-dependent changes in dendritic branching, spine structure, and AMPAR-mediated synaptic transmission.

Mice The generation of muskelin homozygous knockout (Mkln1/) mice is described elsewhere (Heisler et al.7). The Mkln1/ mouse line was backcrossed seven generations into the C57BL/6 background before… [+36441 chars]

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